Introduction:
This training course will introduce participants to various in-silico methods for estimating human health toxicological endpoints, including QSAR models and read-across techniques. The course is designed for participants with limited knowledge on the topic and that are approaching them for the first time.
This training will provide you with the basic knowledge on how to use models and read-across techniques to retrieve toxicological information. You will learn about the basic characteristics and functions of some tools with free access.
Program:
The course will focus on the following topics:
- Human Risk Assessment
- Introduction
- Methods for gathering information on toxicity
- QSARs
- QSAR and SAR
- Endpoint that QSAR can predict
- Commonly used QSAR modelling systems
- OECD principles for QSAR models validation
- QSAR workflow
- Types of QSARs
- The concept of “applicability domain”
- QMRF and QPRF
- Substance identifiers and chemistry
- Main identifiers
- How to use them
- Examples/Exercises
- Molecular properties
- Chemical similarity
- Definition
- READ-Across approach
- Similarity and limits
- In silico tools
- Statistical
- Expert-ruled based
- Examples/Exercises
To whom:
This course is addressed to structured companies’ regulatory affairs and assessors who needs to deepen their knowledge on in silico tools for toxicology.
Teacher/Speaker:
Chiara Marelli
Language:
Italian
(available in English upon request)
Duration:
4 hours
Cost:
350 €/person
